Mooooooooooooooooo............ The Salmonella Website The University of Liverpool
  Proposal and objectives Home
 

Immunology
Immunological responses to natural infections

 Mathematical modelling
Modelling Salmonella infection in cattle

 Space-time analysis
Spatial and temporal patterns in Salmonella

 Literature review
Systematic review of Salmonella literature
 
Understanding the dynamics of endemic and epidemic Salmonella infections in cattle:
A comparative modelling approach

Proposal

This study proposes a comparative modelling approach to identify the key features of the epidemiology of contrasting strains of Salmonella in cattle and pigs; for example S. typhimurium DT104, S. Dublin and S. Derby. The effect of a number of epidemiological parameters on the long term dynamic behaviour of these pathogens both within and between herds including the role of immunity, virulence and pathogen survival was considered. In addition, both cell-mediated and humoral immunity was explored with the aim of identifying reliable tests of the immune response for future epidemiological studies.

Objectives

Mathematical models of Salmonella infection

To formulate, paramaterise and explore the behaviour of mathematical models of the within and between herd transmission of endemic and epidemic strains of Salmonella

Immunological responses to natural infections*

To develop and evaluate methods for measuring immunological responses to Salmonella spp. infection in cattle for further epidemiological studies of herd immunity.

Space-time analysis of salmonella incidents in livestock

To explore and compare the spatial and temporal patterns of S. Typhimurium DT104 and other Salmonella serotypes

Systematic Review of the literature

To conduct and publish an updateable web based searchable Systematic Review of the literature on the epidemiology and immunology of Salmonella in livestock.

*Due to problems encountered during work on this objective an alternate objective was added:

Quantitative microbiology of endemic and epidemic strains of Salmonella on naturally infected farms.

To collect samples from farms with a recent history of Salmonella infection and test for the presence of Salmonella.
Home | Immunology | Mathematical modelling | Space-time analysis | Literature review